Oxacillin sodium monohydrate
Oxacillin sodium monohydrate
CAS: 7240-38-2
Molecular Formula: C19H18N3NaO5S
Oxacillin sodium monohydrate - Names and Identifiers
Oxacillin sodium monohydrate - Physico-chemical Properties
| Molecular Formula | C19H18N3NaO5S |
| Molar Mass | 423.42 |
| Melting Point | 188 C |
| Boling Point | 687℃ |
| Flash Point | >110°(230°F) |
| Water Solubility | Freely soluble in water |
| Storage Condition | 2-8℃ |
| Refractive Index | 205 |
| MDL | MFCD00167146 |
| Physical and Chemical Properties | White crystalline powder. Melting point of 188 ° C (decomposition), soluble in water, methanol, dimethyl sulfoxide, water-soluble ethanol, chloroform, very slightly soluble in acetone, butanol, insoluble in ether, benzene. |
| Use | Uses semi-synthetic acid-resistant and enzyme-resistant penicillin. It is mainly used for drug-resistant Staphylococcus aureus infection, such as septicemia, Pneumonia, purulent meningitis and osteomyelitis. |
Oxacillin sodium monohydrate - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
Oxacillin sodium monohydrate - Study on the effect of excipients on the stability of oxacillin sodium by gas chromatography
From VIP Journal Professional Edition
Author:
Wang Zuofeng ,< a href = "https://xueshu.baidu.com/s?wd=author: (Tang Qizhao) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Tang Qizhao ,< A href = "https://xueshu.baidu.com/s?wd=author: (Zhang Puhai) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Zhang Puhai
Summary:
P> the effects of common excipients such as stearic acid, magnesium stearate, starch, talc and calcium carbonate on the stability of penicillin sodium and ampicillin were studied by using a programmed pyrolysis-gas chromatography (GC) detection system and infrared spectroscopy. The experimental results show that there is a solid phase reaction between stearic acid and penicillin sodium, and it is not suitable to be used as an excipient for solid preparation of penicillin sodium. Other excipients do not have this phenomenon under the same conditions. This is consistent with the results of differential thermal analysis.keywords:
gas chromatography excipient penicillin sodium phenazole
DOI:
CNKI:SUN:ZGYD. 0.1989-01-002
cited:
Year:
1989
Last Update：2024-01-02 23:10:35
Oxacillin sodium monohydrate - Determination of oxacillin sodium by polarimetry
From VIP
Author:
Summary:
determination of benzopenicillin sodium content Chinese pharmacopoeia adopts dual phase neutralization method. although the results of this method are relatively accurate, the determination conditions are high and the operation is time-consuming. it is not suitable for pharmaceutical factories and hospitals to control the quality of their products and the needs of rapid analysis. According to the characteristics of optical activity of benzopenicillin sodium ([α]~(20)D 195~214), the author directly applied optical rotation method to determine its content, and compared with pharmacopoeia, the results were satisfactory. In view of the fact that there is no method for the determination of benzopenicillin sodium
keywords:
polarimetry oxacillin neutralization method content determination optical rotation penicillin sodium measurement conditions comparison of results product quality control quick analysis
Year:
1991
Last Update：2023-08-16 22:09:50
Oxacillin sodium monohydrate - Determination of organic solvent butyl acetate residues in oxacillin sodium
From VIP Journal Professional Edition
Author:
Dou Ailan , Zhong Hua , Hao Lixiao , Li Qingcui , Wang Weixin
Summary:
organic solvents often remain in the process of preparation of some drugs, which affects the safety of drug use. limit tests for residual solvents of some antibiotics have been included in the British Pharmacopoeia (BP1988) and the United States Pharmacopoeia (USP,1990). In this paper, the above tests 401 organic support as stationary phase, n-amyl alcohol as internal standard, column temperature 160 ℃,FID detector and gas chromatography to investigate the residual solvent butyl acetate in benzopenicillin sodium. 21 batches of products from Taiyuan pharmaceutical factory and Shanghai third pharmaceutical factory in the past 3 years were determined, and the residual amount of butyl acetate was 0.130% ~ 0.690%.
keywords:
oxacillin butyl acetate chromatography gas phase
DOI:
CNKI:SUN:SXYX. 0.1994-S1-015
Year:
1994
Last Update：2023-08-16 22:09:50
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